Evolution-guided adaptation of an adenylation domain substrate specificity to an unusual amino acid

Adenylation domains CcbC and LmbC control the specific incorporation of amino acid precursors in the biosynthesis of lincosamide antibiotics celesticetin and lincomycin. Both proteins originate from a common L-proline-specific ancestor, but LmbC was evolutionary adapted to use an unusual substrate,...

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Detalles Bibliográficos
Autores principales: Vobruba, Simon, Kadlcik, Stanislav, Gazak, Radek, Janata, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730197/
https://www.ncbi.nlm.nih.gov/pubmed/29240815
http://dx.doi.org/10.1371/journal.pone.0189684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730197/
https://www.ncbi.nlm.nih.gov/pubmed/29240815
http://dx.doi.org/10.1371/journal.pone.0189684

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