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Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension

The grainyhead-like (grhl) transcription factors play crucial roles in craniofacial development, epithelial morphogenesis, neural tube closure, and dorso-ventral patterning. By utilising the zebrafish to differentially regulate expression of family members grhl2b and grhl3, we show that both genes r...

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Detalles Bibliográficos
Autores principales: Miles, Lee B., Darido, Charbel, Kaslin, Jan, Heath, Joan K., Jane, Stephen M., Dworkin, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730563/
https://www.ncbi.nlm.nih.gov/pubmed/29242584
http://dx.doi.org/10.1038/s41598-017-17898-7