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Hybrid splicing minigene and antisense oligonucleotides as efficient tools to determine functional protein/RNA interactions

Alternative splicing is a complex process that provides a high diversity of proteins from a limited number of protein-coding genes. It is governed by multiple regulatory factors, including RNA-binding proteins (RBPs), that bind to specific RNA sequences embedded in a specific structure. The ability...

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Detalles Bibliográficos
Autores principales: Cywoniuk, Piotr, Taylor, Katarzyna, Sznajder, Łukasz J., Sobczak, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730568/
https://www.ncbi.nlm.nih.gov/pubmed/29242583
http://dx.doi.org/10.1038/s41598-017-17816-x