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Parallelogram based approach for in vivo dose estimation of genotoxic metabolites in humans with relevance to reduction of animal experiments

When employing metabolism studies of genotoxic compounds/metabolites and cancer tests for risk estimation, low exposure doses in humans are roughly extrapolated from high exposure doses in animals. An improvement is to measure the in vivo dose, i.e. area under concentration-time curve (AUC), of the...

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Detalles Bibliográficos
Autores principales: Motwani, Hitesh V., Frostne, Cecilia, Törnqvist, Margareta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730592/
https://www.ncbi.nlm.nih.gov/pubmed/29242644
http://dx.doi.org/10.1038/s41598-017-17692-5