Mutational signatures of non‐homologous and polymerase theta‐mediated end‐joining in embryonic stem cells

Cells employ potentially mutagenic DNA repair mechanisms to avoid the detrimental effects of chromosome breaks on cell survival. While classical non‐homologous end‐joining (cNHEJ) is largely error‐free, alternative end‐joining pathways have been described that are intrinsically mutagenic. Which end‐...

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Detalles Bibliográficos
Autores principales: Schimmel, Joost, Kool, Hanneke, van Schendel, Robin, Tijsterman, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730883/
https://www.ncbi.nlm.nih.gov/pubmed/29079701
http://dx.doi.org/10.15252/embj.201796948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730883/
https://www.ncbi.nlm.nih.gov/pubmed/29079701
http://dx.doi.org/10.15252/embj.201796948

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