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Genetic circuit characterization and debugging using RNA‐seq

Genetic circuits implement computational operations within a cell. Debugging them is difficult because their function is defined by multiple states (e.g., combinations of inputs) that vary in time. Here, we develop RNA‐seq methods that enable the simultaneous measurement of: (i) the states of intern...

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Detalles Bibliográficos
Autores principales: Gorochowski, Thomas E, Espah Borujeni, Amin, Park, Yongjin, Nielsen, Alec AK, Zhang, Jing, Der, Bryan S, Gordon, D Benjamin, Voigt, Christopher A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731345/
https://www.ncbi.nlm.nih.gov/pubmed/29122925
http://dx.doi.org/10.15252/msb.20167461