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Inhibition of lysosomal Ca(2+) signalling disrupts dendritic spine structure and impairs wound healing in neurons

A growing body of evidence suggests that lysosomes, which have traditionally been regarded as degradative organelles, can function as Ca(2+) stores, regulated by the second messenger nicotinic acid adenine dinucleotide phosphate (NAADP). We previously demonstrated that in hippocampal pyramidal neuro...

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Detalles Bibliográficos
Autores principales: Padamsey, Zahid, McGuinness, Lindsay, Emptage, Nigel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731510/
https://www.ncbi.nlm.nih.gov/pubmed/29259727
http://dx.doi.org/10.1080/19420889.2017.1344802