Dual ET(A)/ET(B) blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension

Dysregulated metabolism and rarefaction of the capillary network play a critical role in pulmonary arterial hypertension (PAH) etiology. They are associated with a decrease in perfusion of the lungs, skeletal muscles, and right ventricle (RV). Previous studies suggested that endothelin-1 (ET-1) modu...

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Detalles Bibliográficos
Autores principales: Nadeau, Valerie, Potus, Francois, Boucherat, Olivier, Paradis, Renee, Tremblay, Eve, Iglarz, Marc, Paulin, Roxane, Bonnet, Sebastien, Provencher, Steeve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731731/
https://www.ncbi.nlm.nih.gov/pubmed/29064353
http://dx.doi.org/10.1177/2045893217741429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731731/
https://www.ncbi.nlm.nih.gov/pubmed/29064353
http://dx.doi.org/10.1177/2045893217741429

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