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Dual ET(A)/ET(B) blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension

Dysregulated metabolism and rarefaction of the capillary network play a critical role in pulmonary arterial hypertension (PAH) etiology. They are associated with a decrease in perfusion of the lungs, skeletal muscles, and right ventricle (RV). Previous studies suggested that endothelin-1 (ET-1) modu...

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Detalles Bibliográficos
Autores principales:	Nadeau, Valerie, Potus, Francois, Boucherat, Olivier, Paradis, Renee, Tremblay, Eve, Iglarz, Marc, Paulin, Roxane, Bonnet, Sebastien, Provencher, Steeve
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731731/ https://www.ncbi.nlm.nih.gov/pubmed/29064353 http://dx.doi.org/10.1177/2045893217741429

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