Tumor suppressor protein p53-mediated repression of human mitotic centromere-associated kinesin gene expression is exerted via down-regulation of Sp1 level

The repressive role of p53 on the human mitotic centromere-associated kinesin (MCAK) core promoter from ‒266 to +54, relative to the transcription start site, has been determined. The MCAK mRNA and protein levels were 2.1- and 3.0-fold higher, respectively, in HCT116 (p53(‒/‒)) than in HCT116 (p53(+...

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Detalles Bibliográficos
Autores principales: Jun, Do Youn, Lee, Ji Young, Park, Hae Sun, Lee, Yun Han, Kim, Young Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731752/
https://www.ncbi.nlm.nih.gov/pubmed/29244835
http://dx.doi.org/10.1371/journal.pone.0189698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731752/
https://www.ncbi.nlm.nih.gov/pubmed/29244835
http://dx.doi.org/10.1371/journal.pone.0189698

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