Lentivirus-mediated RNA interference targeting FAMLF-1 inhibits cell growth and enhances cell differentiation of acute myeloid leukemia partially differentiated cells via inhibition of AKT and c-MYC

Genetic heterogeneity is the basis of clinical heterogeneity among different subtypes of AML. We have successfully cloned a gene related to AML termed FAMLF from a FAB-M2 patient's sample of a second largest AML pedigree. Then we revealed at least three splice variants, named as FAMLF-1, FAMLF-...

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Detalles Bibliográficos
Autores principales: Huang, Yuan-Mao, Zheng, Yi, Li, Jing-Gang, Wang, Xue-Chun, Wang, Ze-Chuan, Chen, Wan-Ling, Pan, Li-Li, Li, Yang, Luo, Dong-Feng, Wang, Shao-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731881/
https://www.ncbi.nlm.nih.gov/pubmed/29254171
http://dx.doi.org/10.18632/oncotarget.21276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731881/
https://www.ncbi.nlm.nih.gov/pubmed/29254171
http://dx.doi.org/10.18632/oncotarget.21276

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