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Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation

Viperin is an interferon-inducible antiviral protein, responsible for antiviral response to a variety of viral infections. Here, we show that silencing viperin by antisense oligonucleotides (ASO) protects against diet-induced glucose intolerance, and yet exacerbates adipose tissue inflammation. In h...

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Autores principales: Qi, Zhengtang, Xia, Jie, Xue, Xiangli, Liu, Jiatong, Liu, Weina, Ding, Shuzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731885/
https://www.ncbi.nlm.nih.gov/pubmed/29254175
http://dx.doi.org/10.18632/oncotarget.20724
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author Qi, Zhengtang
Xia, Jie
Xue, Xiangli
Liu, Jiatong
Liu, Weina
Ding, Shuzhe
author_facet Qi, Zhengtang
Xia, Jie
Xue, Xiangli
Liu, Jiatong
Liu, Weina
Ding, Shuzhe
author_sort Qi, Zhengtang
collection PubMed
description Viperin is an interferon-inducible antiviral protein, responsible for antiviral response to a variety of viral infections. Here, we show that silencing viperin by antisense oligonucleotides (ASO) protects against diet-induced glucose intolerance, and yet exacerbates adipose tissue inflammation. In high-fat diet-fed mice, viperin ASO improves glucose homeostasis, reduces plasma triglyceride concentrations and ameliorates diet-induced hepatic steatosis. Peripheral delivery of viperin by adeno-associated virus elevates fasting plasma glucose and insulin concentrations and reduces insulin-stimulated glucose uptake in skeletal muscle. Viperin overexpression reduces epinephrine- stimulated lipolysis in white adipose tissue, whereas viperin ASO increases expression of lipolytic genes. Targeting viperin by antisense oligonucleotides promotes reciprocal regulation of hepatic and adipose lipogenesis by reducing hepatic lipid content and increasing triacylglycerol content in adipose tissue. These findings reveal viperin as an important target to improve glucose metabolism, and suggest that suppressing antiviral potential may improve the metabolic adaptability to high-fat diet.
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spelling pubmed-57318852017-12-17 Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation Qi, Zhengtang Xia, Jie Xue, Xiangli Liu, Jiatong Liu, Weina Ding, Shuzhe Oncotarget Research Paper Viperin is an interferon-inducible antiviral protein, responsible for antiviral response to a variety of viral infections. Here, we show that silencing viperin by antisense oligonucleotides (ASO) protects against diet-induced glucose intolerance, and yet exacerbates adipose tissue inflammation. In high-fat diet-fed mice, viperin ASO improves glucose homeostasis, reduces plasma triglyceride concentrations and ameliorates diet-induced hepatic steatosis. Peripheral delivery of viperin by adeno-associated virus elevates fasting plasma glucose and insulin concentrations and reduces insulin-stimulated glucose uptake in skeletal muscle. Viperin overexpression reduces epinephrine- stimulated lipolysis in white adipose tissue, whereas viperin ASO increases expression of lipolytic genes. Targeting viperin by antisense oligonucleotides promotes reciprocal regulation of hepatic and adipose lipogenesis by reducing hepatic lipid content and increasing triacylglycerol content in adipose tissue. These findings reveal viperin as an important target to improve glucose metabolism, and suggest that suppressing antiviral potential may improve the metabolic adaptability to high-fat diet. Impact Journals LLC 2017-09-08 /pmc/articles/PMC5731885/ /pubmed/29254175 http://dx.doi.org/10.18632/oncotarget.20724 Text en Copyright: © 2017 Qi et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Qi, Zhengtang
Xia, Jie
Xue, Xiangli
Liu, Jiatong
Liu, Weina
Ding, Shuzhe
Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation
title Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation
title_full Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation
title_fullStr Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation
title_full_unstemmed Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation
title_short Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation
title_sort targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731885/
https://www.ncbi.nlm.nih.gov/pubmed/29254175
http://dx.doi.org/10.18632/oncotarget.20724
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