Metformin induces cell cycle arrest at the G1 phase through E2F8 suppression in lung cancer cells

A target molecule responsible for cell cycle arrest by metformin was discovered using a gene chip array in lung cancer cells and the effect of metformin on E2F8 was assessed. The siRNA-mediated knockdown of E2F8 significantly suppressed G1-S progression while ectopic expression of E2F8 relieved metf...

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Detalles Bibliográficos
Autores principales: Jin, Dong Hao, Kim, Yujin, Lee, Bo Bin, Han, Joungho, Kim, Hong Kwan, Shim, Young Mog, Kim, Duk-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731892/
https://www.ncbi.nlm.nih.gov/pubmed/29254182
http://dx.doi.org/10.18632/oncotarget.21552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731892/
https://www.ncbi.nlm.nih.gov/pubmed/29254182
http://dx.doi.org/10.18632/oncotarget.21552

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