The ubiquitous ‘cancer mutational signature’ 5 occurs specifically in cancers with deleted FHIT alleles

The FHIT gene is located at the fragile FRA3B locus where activation by carcinogen-induced and endogenous replication stress causes FHIT deletions even in normal cells over a lifetime. Our lab has shown that loss of FHIT expression causes genome instability and provides single-strand DNA substrates...

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Detalles Bibliográficos
Autores principales: Volinia, Stefano, Druck, Teresa, Paisie, Carolyn A., Schrock, Morgan S., Huebner, Kay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731946/
https://www.ncbi.nlm.nih.gov/pubmed/29254236
http://dx.doi.org/10.18632/oncotarget.22321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731946/
https://www.ncbi.nlm.nih.gov/pubmed/29254236
http://dx.doi.org/10.18632/oncotarget.22321

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