Anti-LINGO-1 has no detectable immunomodulatory effects in preclinical and phase 1 studies

OBJECTIVE: To evaluate whether the anti-LINGO-1 antibody has immunomodulatory effects. METHODS: Human peripheral blood mononuclear cells (hPBMCs), rat splenocytes, and rat CD4(+) T cells were assessed to determine whether LINGO-1 was expressed and was inducible. Anti-LINGO-1 Li81 (0.1–30 μg/mL) effe...

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Detalles Bibliográficos
Autores principales: Ranger, Ann, Ray, Soma, Szak, Suzanne, Dearth, Andrea, Allaire, Norm, Murray, Ronald, Gardner, Rebecca, Cadavid, Diego, Mi, Sha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732005/
https://www.ncbi.nlm.nih.gov/pubmed/29259995
http://dx.doi.org/10.1212/NXI.0000000000000417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732005/
https://www.ncbi.nlm.nih.gov/pubmed/29259995
http://dx.doi.org/10.1212/NXI.0000000000000417

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