Synthesis of the C(1)–C(13) Fragment of Leiodermatolide via Hydrogen-Mediated C–C Bond Formation

[Image: see text] The C(1)–C(13) fragment of the antimitotic marine macrolide leiodermatolide is prepared in seven steps via hydrogenative and transfer-hydrogenative reductive C–C couplings. A hydrogen-mediated reductive coupling of acetylene with a Roche-type aldehyde is used to construct C(7)–C(13...

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Detalles Bibliográficos
Autores principales: Roane, James, Wippich, Julian, Ramgren, Stephen D., Krische, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732063/
https://www.ncbi.nlm.nih.gov/pubmed/29168383
http://dx.doi.org/10.1021/acs.orglett.7b03351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732063/
https://www.ncbi.nlm.nih.gov/pubmed/29168383
http://dx.doi.org/10.1021/acs.orglett.7b03351

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