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Synthesis of the C(1)–C(13) Fragment of Leiodermatolide via Hydrogen-Mediated C–C Bond Formation

[Image: see text] The C(1)–C(13) fragment of the antimitotic marine macrolide leiodermatolide is prepared in seven steps via hydrogenative and transfer-hydrogenative reductive C–C couplings. A hydrogen-mediated reductive coupling of acetylene with a Roche-type aldehyde is used to construct C(7)–C(13...

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Detalles Bibliográficos
Autores principales:	Roane, James, Wippich, Julian, Ramgren, Stephen D., Krische, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732063/ https://www.ncbi.nlm.nih.gov/pubmed/29168383 http://dx.doi.org/10.1021/acs.orglett.7b03351

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