Modelling mosquito infection at natural parasite densities identifies drugs targeting EF2, PI4K or ATP4 as key candidates for interrupting malaria transmission

Eradication of malaria requires a novel type of drug that blocks transmission from the human to the mosquito host, but selection of such a drug is hampered by a lack of translational models. Experimental mosquito infections yield infection intensities that are substantially higher than observed in n...

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Detalles Bibliográficos
Autores principales: Dechering, Koen J., Duerr, Hans-Peter, Koolen, Karin M. J., Gemert, Geert-Jan van, Bousema, Teun, Burrows, Jeremy, Leroy, Didier, Sauerwein, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732164/
https://www.ncbi.nlm.nih.gov/pubmed/29247222
http://dx.doi.org/10.1038/s41598-017-16671-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732164/
https://www.ncbi.nlm.nih.gov/pubmed/29247222
http://dx.doi.org/10.1038/s41598-017-16671-0

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