α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling

α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking. In Parkinson’s disease (PD) and several other neurodegenerative disorders, aberrant oligomerization and aggregation of α-synuclein lead to synaptic dysfunction and neurotoxicity. Despite evidence that α-synuclein...

Descripción completa

Detalles Bibliográficos
Autores principales: Medeiros, Audrey T., Soll, Lindsey G., Tessari, Isabella, Bubacco, Luigi, Morgan, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732215/
https://www.ncbi.nlm.nih.gov/pubmed/29321725
http://dx.doi.org/10.3389/fncel.2017.00388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732215/
https://www.ncbi.nlm.nih.gov/pubmed/29321725
http://dx.doi.org/10.3389/fncel.2017.00388

Ejemplares similares