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α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling

α-Synuclein is a presynaptic protein that regulates synaptic vesicle (SV) trafficking. In Parkinson’s disease (PD) and several other neurodegenerative disorders, aberrant oligomerization and aggregation of α-synuclein lead to synaptic dysfunction and neurotoxicity. Despite evidence that α-synuclein...

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Detalles Bibliográficos
Autores principales:	Medeiros, Audrey T., Soll, Lindsey G., Tessari, Isabella, Bubacco, Luigi, Morgan, Jennifer R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732215/ https://www.ncbi.nlm.nih.gov/pubmed/29321725 http://dx.doi.org/10.3389/fncel.2017.00388

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