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Vitamin K epoxide reductase and its paralogous enzyme have different structures and functions

Vitamin K epoxide reductase (VKOR) is an essential enzyme for vitamin K-dependent carboxylation, while the physiological function of its paralogous enzyme VKOR-like (VKORL) is yet unknown. Although these two enzymes share approximately 50% protein sequence homology, the membrane topology of VKOR is...

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Detalles Bibliográficos
Autores principales: Sinhadri, Balaji Chandra Sekhar, Jin, Da-Yun, Stafford, Darrel W., Tie, Jian-Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732223/
https://www.ncbi.nlm.nih.gov/pubmed/29247216
http://dx.doi.org/10.1038/s41598-017-18008-3