Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies

BACKGROUND: Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions. To assign weights, the gold standard is to use external weights from an independent study....

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Detalles Bibliográficos
Autores principales: Hüls, Anke, Krämer, Ursula, Carlsten, Christopher, Schikowski, Tamara, Ickstadt, Katja, Schwender, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732390/
https://www.ncbi.nlm.nih.gov/pubmed/29246113
http://dx.doi.org/10.1186/s12863-017-0586-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732390/
https://www.ncbi.nlm.nih.gov/pubmed/29246113
http://dx.doi.org/10.1186/s12863-017-0586-3

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