Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the cancer types with poor prognosis. To effectively treat HCC, new molecular targets and therapeutic approaches must be identified. 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine monophosphate (IMP) cyclohydrolase (ATIC),...

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Detalles Bibliográficos
Autores principales: Li, Minjing, Jin, Changzhu, Xu, Maolei, Zhou, Ling, Li, Defang, Yin, Yancun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732395/
https://www.ncbi.nlm.nih.gov/pubmed/29246230
http://dx.doi.org/10.1186/s12964-017-0208-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732395/
https://www.ncbi.nlm.nih.gov/pubmed/29246230
http://dx.doi.org/10.1186/s12964-017-0208-8

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