Overexpression of parkin rescues the defective mitochondrial phenotype and the increased apoptosis of Cockayne Syndrome A cells

The ERCC8/CSA gene encodes a WD-40 repeat protein (CSA) that is part of a E3-ubiquitin ligase/COP9 signalosome complex. When mutated, CSA causes the Cockayne Syndrome group A (CS-A), a rare recessive progeroid disorder characterized by sun sensitivity and neurodevelopmental abnormalities. CS-A cells...

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Detalles Bibliográficos
Autores principales: Pascucci, Barbara, D’Errico, Mariarosaria, Romagnoli, Alessandra, De Nuccio, Chiara, Savino, Miriam, Pietraforte, Donatella, Lanzafame, Manuela, Calcagnile, Angelo Salvatore, Fortini, Paola, Baccarini, Sara, Orioli, Donata, Degan, Paolo, Visentin, Sergio, Stefanini, Miria, Isidoro, Ciro, Fimia, Gian Maria, Dogliotti, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732694/
https://www.ncbi.nlm.nih.gov/pubmed/29262528
http://dx.doi.org/10.18632/oncotarget.9913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732694/
https://www.ncbi.nlm.nih.gov/pubmed/29262528
http://dx.doi.org/10.18632/oncotarget.9913

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