Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling

Cucurbitacin B (CuB) is a natural tetracyclic triterpene product and displays antitumor activity across a wide array of cancers. In this study, we explored the anti-pancreatic cancer activity of CuB alone and in combination with SCH772984, an ERK inhibitor, in vitro and in vivo. CuB inhibited prolif...

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Detalles Bibliográficos
Autores principales: Zhou, Jingkai, Zhao, Tiangang, Ma, Linfeng, Liang, Min, Guo, Ying-Jie, Zhao, Li-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732720/
https://www.ncbi.nlm.nih.gov/pubmed/29262554
http://dx.doi.org/10.18632/oncotarget.21704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732720/
https://www.ncbi.nlm.nih.gov/pubmed/29262554
http://dx.doi.org/10.18632/oncotarget.21704

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