Metabolism, pharmacokinetics, and bioavailability of ZB716, a Steroidal Selective Estrogen Receptor Downregulator (SERD)

ZB716 is a selective estrogen receptor downregulator (SERD) with excellent oral bioavailability and superior efficacy. In this study, we investigate the in vitro and in vivo metabolism and the pharmacokinetics of ZB716 by incubation with liver microsomes, liver cytosol, and by orally dosing rodents....

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Detalles Bibliográficos
Autores principales: Zhang, Changde, Guo, Shanchun, Yang, Lin, Liu, Jiawang, Zheng, Shilong, Zhong, Qiu, Zhang, Qiang, Wang, Guangdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732773/
https://www.ncbi.nlm.nih.gov/pubmed/29262607
http://dx.doi.org/10.18632/oncotarget.21808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732773/
https://www.ncbi.nlm.nih.gov/pubmed/29262607
http://dx.doi.org/10.18632/oncotarget.21808

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