PARP inhibition causes premature loss of cohesion in cancer cells

Poly(ADP-ribose) polymerases (PARPs) regulate various aspects of cellular function including mitotic progression. Although PARP inhibitors have been undergoing various clinical trials and the PARP1/2 inhibitor olaparib was approved as monotherapy for BRCA-mutated ovarian cancer, their mode of action...

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Detalles Bibliográficos
Autores principales: Kukolj, Eva, Kaufmann, Tanja, Dick, Amalie E., Zeillinger, Robert, Gerlich, Daniel W., Slade, Dea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732777/
https://www.ncbi.nlm.nih.gov/pubmed/29262611
http://dx.doi.org/10.18632/oncotarget.21879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732777/
https://www.ncbi.nlm.nih.gov/pubmed/29262611
http://dx.doi.org/10.18632/oncotarget.21879

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