The fate of murine double minute X (MdmX) is dictated by distinct signaling pathways through murine double minute 2 (Mdm2)

Mouse double minute 2 (Mdm2) and MdmX dimerize in response to low levels of genotoxic stress to function in a ubiquitinating complex, which signals for destabilization of p53. Under growth conditions, Mdm2 functions as a neddylating ligase, but the importance and extent of MdmX involvement in this p...

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Detalles Bibliográficos
Autores principales: Hauck, Paula M., Wolf, Eric R., Olivos, David J., McAtarsney, Ciaran P., Mayo, Lindsey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732819/
https://www.ncbi.nlm.nih.gov/pubmed/29262653
http://dx.doi.org/10.18632/oncotarget.22320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732819/
https://www.ncbi.nlm.nih.gov/pubmed/29262653
http://dx.doi.org/10.18632/oncotarget.22320

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