Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)

Cancer cells reprogram their metabolism and energy production to sustain increased growth, enable metastasis and overcome resistance to cancer treatments. Although primary roles for many metabolic proteins have been identified, some are promiscuous in regards to the reaction they catalyze. To effici...

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Detalles Bibliográficos
Autores principales: Unterlass, Judith E., Wood, Robert J., Baslé, Arnaud, Tucker, Julie, Cano, Céline, Noble, Martin M.E., Curtin, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732821/
https://www.ncbi.nlm.nih.gov/pubmed/29262655
http://dx.doi.org/10.18632/oncotarget.22327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732821/
https://www.ncbi.nlm.nih.gov/pubmed/29262655
http://dx.doi.org/10.18632/oncotarget.22327

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