Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology

Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease modeling, cell therapy, drug screening and personalized medicine. Computational models can be used to interpret experimental findings in iPSC-CMs, provide mechanistic insights, and translate these find...

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Detalles Bibliográficos
Autores principales: Lei, Chon Lok, Wang, Ken, Clerx, Michael, Johnstone, Ross H., Hortigon-Vinagre, Maria P., Zamora, Victor, Allan, Andrew, Smith, Godfrey L., Gavaghan, David J., Mirams, Gary R., Polonchuk, Liudmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732978/
https://www.ncbi.nlm.nih.gov/pubmed/29311950
http://dx.doi.org/10.3389/fphys.2017.00986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732978/
https://www.ncbi.nlm.nih.gov/pubmed/29311950
http://dx.doi.org/10.3389/fphys.2017.00986

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