Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases

DNA editing deaminases (APOBECs) are implicated in generation of mutations in somatic cells during tumorigenesis. APOBEC-dependent mutagenesis is thought to occur during transient exposure of unprotected single-stranded DNA. Mutations frequently occur in clusters (kataegis). We investigated mechanis...

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Detalles Bibliográficos
Autores principales: Lada, Artem G., Stepchenkova, Elena I., Zhuk, Anna S., Kliver, Sergei F., Rogozin, Igor B., Polev, Dmitrii E., Dhar, Alok, Pavlov, Youri I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733079/
https://www.ncbi.nlm.nih.gov/pubmed/29312434
http://dx.doi.org/10.3389/fgene.2017.00202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733079/
https://www.ncbi.nlm.nih.gov/pubmed/29312434
http://dx.doi.org/10.3389/fgene.2017.00202

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