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Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression
To gain insight into how mammalian gene expression is controlled by rapidly evolving regulatory elements, we jointly analysed promoter and enhancer activity with downstream transcription levels in liver samples from fifteen species. Genes associated with complex regulatory landscapes generally exhib...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733139/ https://www.ncbi.nlm.nih.gov/pubmed/29180706 http://dx.doi.org/10.1038/s41559-017-0377-2 |