Functional selectivity of GPCR-directed drug action through location bias

G protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β(2)-adrenergic GPCR can activate Gs-linkedcyclic AMP (cAMP) signaling from endosomes. We show here that the homologous human β(1)-adrenergic receptor initiates...

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Detalles Bibliográficos
Autores principales: Irannejad, Roshanak, Pessino, Veronica, Mika, Delphine, Huang, Bo, Wedegaertner, Philip B., Conti, Marco, von Zastrow, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733145/
https://www.ncbi.nlm.nih.gov/pubmed/28553949
http://dx.doi.org/10.1038/nchembio.2389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733145/
https://www.ncbi.nlm.nih.gov/pubmed/28553949
http://dx.doi.org/10.1038/nchembio.2389

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