Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease

Presenilin 1 and presenilin 2 (PS1 and PS2) play a critical role in γ-secretase-mediated cleavage of amyloid-β precursor protein (APP) and the subsequent generation of β-amyloid peptides. The purpose of the present study was to test whether PS2 mutation accelerates the onset of contextual fear memor...

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Detalles Bibliográficos
Autores principales: Kishimoto, Yasushi, Fukumoto, Kai, Nagai, Mika, Mizuguchi, Ayaka, Kobashi, Yuiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733185/
https://www.ncbi.nlm.nih.gov/pubmed/29333315
http://dx.doi.org/10.1155/2017/8584205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733185/
https://www.ncbi.nlm.nih.gov/pubmed/29333315
http://dx.doi.org/10.1155/2017/8584205

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