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Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor Protein/Presenilin 2 Mouse Model of Alzheimer's Disease
Presenilin 1 and presenilin 2 (PS1 and PS2) play a critical role in γ-secretase-mediated cleavage of amyloid-β precursor protein (APP) and the subsequent generation of β-amyloid peptides. The purpose of the present study was to test whether PS2 mutation accelerates the onset of contextual fear memor...
Autores principales: | Kishimoto, Yasushi, Fukumoto, Kai, Nagai, Mika, Mizuguchi, Ayaka, Kobashi, Yuiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733185/ https://www.ncbi.nlm.nih.gov/pubmed/29333315 http://dx.doi.org/10.1155/2017/8584205 |
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