Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid

[Image: see text] A published study of structural features associated with the aerobic and anaerobic activities of 4- and 5-nitroimidazoles had found that the 3-nitro isomer of pretomanid, 8, displayed interesting potencies, including against nitroreductase mutant Mycobacterium tuberculosis. However...

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Detalles Bibliográficos
Autores principales: Thompson, Andrew M., Bonnet, Muriel, Lee, Ho H., Franzblau, Scott G., Wan, Baojie, Wong, George S., Cooper, Christopher B., Denny, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733301/
https://www.ncbi.nlm.nih.gov/pubmed/29259747
http://dx.doi.org/10.1021/acsmedchemlett.7b00356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733301/
https://www.ncbi.nlm.nih.gov/pubmed/29259747
http://dx.doi.org/10.1021/acsmedchemlett.7b00356

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