A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response (UPR) increases ER-protein-folding capacity to restore protein-folding homeostasis. Unfolded proteins activate UPR signaling across the ER membrane to the nucleus by promoting oligomerization of IRE1,...

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Detalles Bibliográficos
Autores principales: Amin-Wetzel, Niko, Saunders, Reuben A., Kamphuis, Maarten J., Rato, Claudia, Preissler, Steffen, Harding, Heather P., Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733394/
https://www.ncbi.nlm.nih.gov/pubmed/29198525
http://dx.doi.org/10.1016/j.cell.2017.10.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733394/
https://www.ncbi.nlm.nih.gov/pubmed/29198525
http://dx.doi.org/10.1016/j.cell.2017.10.040

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