Gender and Age Effects on the Trajectory of Depression in Opioid Users during Methadone Maintenance Treatment

INTRODUCTION: Both heroin use and depression are significant health problems. Methadone maintenance treatment (MMT) can be of great benefit to heroin users. However, changes in the level of depression in heroin users during MMT are not clear. Gender and age are also important factors in the developm...

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Autores principales: Wang, Peng-Wei, Lin, Huang-Chi, Yang, Yi-Hsin Connie, Hsu, Chih-Yao, Chung, Kuan-Sheng, Wu, Hung-Chi, Yen, Cheng-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733537/
https://www.ncbi.nlm.nih.gov/pubmed/29321749
http://dx.doi.org/10.3389/fpsyt.2017.00288
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author Wang, Peng-Wei
Lin, Huang-Chi
Yang, Yi-Hsin Connie
Hsu, Chih-Yao
Chung, Kuan-Sheng
Wu, Hung-Chi
Yen, Cheng-Fang
author_facet Wang, Peng-Wei
Lin, Huang-Chi
Yang, Yi-Hsin Connie
Hsu, Chih-Yao
Chung, Kuan-Sheng
Wu, Hung-Chi
Yen, Cheng-Fang
author_sort Wang, Peng-Wei
collection PubMed
description INTRODUCTION: Both heroin use and depression are significant health problems. Methadone maintenance treatment (MMT) can be of great benefit to heroin users. However, changes in the level of depression in heroin users during MMT are not clear. Gender and age are also important factors in the development of depression, and whether gender and age moderate changes in depression in heroin users during MMT warrants further study. This study aimed to explore: (1) the trajectory of depression in opioid users during MMT and (2) the moderating effects of gender and age on the trajectory of depression in opioid users receiving MMT. METHOD: A total of 294 intravenous heroin users were recruited into this 9-month observational study. The level of depression was measured at the intake interview and at follow-up interviews every 3 months. A latent growth model was used to analyze the trajectory of the level of depression among the participants. RESULTS: Depression improved rapidly during the first 3 months of MMT and slowly after the first 3 months in both the female and male heroin users. There was no gender difference in the level of depression at each follow-up point. The level of depression in the female heroin users decreased faster than that in the male heroin users. In addition, the level of depression in the younger heroin users decreased faster than that in the older subjects. CONCLUSION: Depression in female and younger heroin users improved more rapidly than in male and older subjects, respectively.
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spelling pubmed-57335372018-01-10 Gender and Age Effects on the Trajectory of Depression in Opioid Users during Methadone Maintenance Treatment Wang, Peng-Wei Lin, Huang-Chi Yang, Yi-Hsin Connie Hsu, Chih-Yao Chung, Kuan-Sheng Wu, Hung-Chi Yen, Cheng-Fang Front Psychiatry Psychiatry INTRODUCTION: Both heroin use and depression are significant health problems. Methadone maintenance treatment (MMT) can be of great benefit to heroin users. However, changes in the level of depression in heroin users during MMT are not clear. Gender and age are also important factors in the development of depression, and whether gender and age moderate changes in depression in heroin users during MMT warrants further study. This study aimed to explore: (1) the trajectory of depression in opioid users during MMT and (2) the moderating effects of gender and age on the trajectory of depression in opioid users receiving MMT. METHOD: A total of 294 intravenous heroin users were recruited into this 9-month observational study. The level of depression was measured at the intake interview and at follow-up interviews every 3 months. A latent growth model was used to analyze the trajectory of the level of depression among the participants. RESULTS: Depression improved rapidly during the first 3 months of MMT and slowly after the first 3 months in both the female and male heroin users. There was no gender difference in the level of depression at each follow-up point. The level of depression in the female heroin users decreased faster than that in the male heroin users. In addition, the level of depression in the younger heroin users decreased faster than that in the older subjects. CONCLUSION: Depression in female and younger heroin users improved more rapidly than in male and older subjects, respectively. Frontiers Media S.A. 2017-12-13 /pmc/articles/PMC5733537/ /pubmed/29321749 http://dx.doi.org/10.3389/fpsyt.2017.00288 Text en Copyright © 2017 Wang, Lin, Yang, Hsu, Chung, Wu and Yen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Wang, Peng-Wei
Lin, Huang-Chi
Yang, Yi-Hsin Connie
Hsu, Chih-Yao
Chung, Kuan-Sheng
Wu, Hung-Chi
Yen, Cheng-Fang
Gender and Age Effects on the Trajectory of Depression in Opioid Users during Methadone Maintenance Treatment
title Gender and Age Effects on the Trajectory of Depression in Opioid Users during Methadone Maintenance Treatment
title_full Gender and Age Effects on the Trajectory of Depression in Opioid Users during Methadone Maintenance Treatment
title_fullStr Gender and Age Effects on the Trajectory of Depression in Opioid Users during Methadone Maintenance Treatment
title_full_unstemmed Gender and Age Effects on the Trajectory of Depression in Opioid Users during Methadone Maintenance Treatment
title_short Gender and Age Effects on the Trajectory of Depression in Opioid Users during Methadone Maintenance Treatment
title_sort gender and age effects on the trajectory of depression in opioid users during methadone maintenance treatment
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733537/
https://www.ncbi.nlm.nih.gov/pubmed/29321749
http://dx.doi.org/10.3389/fpsyt.2017.00288
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