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Non-Watson–Crick RNA synthesis suited to origin functions

A templated RNA synthesis is characterized in which G(5′)pp(5′)G accelerates synthesis of A(5′)pp(5′)A from pA and chemically activated ImpA precursors. Similar acceleration is not observable in the presence of UppU, CppC, AppG, AppA, or pG alone. Thus, it seems likely that AppA is templated by GppG...

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Detalles Bibliográficos
Autores principales: Puthenvedu, Deepa, Majerfeld, Irene, Yarus, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733574/
https://www.ncbi.nlm.nih.gov/pubmed/29042506
http://dx.doi.org/10.1261/rna.063974.117