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Ras signaling in aging and metabolic regulation

Aberrant signal transduction downstream of the Ras GTPase has a well-established role in tumorigenesis. Mutations that result in hyperactivation of Ras are responsible for a third of all human cancers. Hence, small molecule inhibitors of the Ras signal transduction cascade have been under intense fo...

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Detalles Bibliográficos
Autor principal: Slack, Cathy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734121/
https://www.ncbi.nlm.nih.gov/pubmed/29276789
http://dx.doi.org/10.3233/NHA-160021