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Ras signaling in aging and metabolic regulation
Aberrant signal transduction downstream of the Ras GTPase has a well-established role in tumorigenesis. Mutations that result in hyperactivation of Ras are responsible for a third of all human cancers. Hence, small molecule inhibitors of the Ras signal transduction cascade have been under intense fo...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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IOS Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734121/ https://www.ncbi.nlm.nih.gov/pubmed/29276789 http://dx.doi.org/10.3233/NHA-160021 |