Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse

mRNA therapeutics hold promise for the treatment of diseases requiring intracellular protein expression and for use in genome editing systems, but mRNA must transfect the desired tissue and cell type to be efficacious. Nanoparticle vectors that deliver the mRNA are often evaluated using mRNA encodin...

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Detalles Bibliográficos
Autores principales: Kauffman, Kevin J., Oberli, Matthias A., Dorkin, J. Robert, Hurtado, Juan E., Kaczmarek, James C., Bhadani, Shivani, Wyckoff, Jeff, Langer, Robert, Jaklenec, Ana, Anderson, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734870/
https://www.ncbi.nlm.nih.gov/pubmed/29499956
http://dx.doi.org/10.1016/j.omtn.2017.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734870/
https://www.ncbi.nlm.nih.gov/pubmed/29499956
http://dx.doi.org/10.1016/j.omtn.2017.11.005

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