Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B

Nanos RNA-binding proteins are required for germline development in metazoans, but the underlying mechanisms remain poorly understood. We have profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs nos-1 and nos-2 in C. elegans. nos-1nos-2 PGCs fail to silence hundreds...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Chih-Yung Sean, Lu, Tu, Seydoux, Geraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734877/
https://www.ncbi.nlm.nih.gov/pubmed/29111977
http://dx.doi.org/10.7554/eLife.30201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734877/
https://www.ncbi.nlm.nih.gov/pubmed/29111977
http://dx.doi.org/10.7554/eLife.30201

Ejemplares similares