Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine

Dihydrofolate reductase (DHFR) is an important enzyme for de novo synthesis of nucleotides in Plasmodium falciparum and it is essential for cell proliferation. DHFR is a well known antimalarial target for drugs like cycloguanil and pyrimethamine which target its inhibition for their pharmacological...

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Detalles Bibliográficos
Autores principales: Pathak, Mallika, Ojha, Himanshu, Tiwari, Anjani K., Sharma, Deepti, Saini, Manisha, Kakkar, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735044/
https://www.ncbi.nlm.nih.gov/pubmed/29256159
http://dx.doi.org/10.1186/s13065-017-0362-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735044/
https://www.ncbi.nlm.nih.gov/pubmed/29256159
http://dx.doi.org/10.1186/s13065-017-0362-5

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