Evolutionary action and structural basis of the allosteric switch controlling β(2)AR functional selectivity

Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing important roles in transducing ligand binding into distinct signaling responses, we...

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Detalles Bibliográficos
Autores principales: Schönegge, Anne-Marie, Gallion, Jonathan, Picard, Louis-Philippe, Wilkins, Angela D., Le Gouill, Christian, Audet, Martin, Stallaert, Wayne, Lohse, Martin J., Kimmel, Marek, Lichtarge, Olivier, Bouvier, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735088/
https://www.ncbi.nlm.nih.gov/pubmed/29255305
http://dx.doi.org/10.1038/s41467-017-02257-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735088/
https://www.ncbi.nlm.nih.gov/pubmed/29255305
http://dx.doi.org/10.1038/s41467-017-02257-x

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