Evolutionary action and structural basis of the allosteric switch controlling β(2)AR functional selectivity

Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing important roles in transducing ligand binding into distinct signaling responses, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Schönegge, Anne-Marie, Gallion, Jonathan, Picard, Louis-Philippe, Wilkins, Angela D., Le Gouill, Christian, Audet, Martin, Stallaert, Wayne, Lohse, Martin J., Kimmel, Marek, Lichtarge, Olivier, Bouvier, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735088/
https://www.ncbi.nlm.nih.gov/pubmed/29255305
http://dx.doi.org/10.1038/s41467-017-02257-x

Ejemplares similares

Ejemplares similares