Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage

Unrepaired DNA lesions are a potent block to replication, leading to replication fork collapse, double-strand DNA breaks, and cell death. Error-prone polymerases overcome this blockade by synthesizing past DNA lesions in a process called translesion synthesis (TLS), but how TLS polymerases gain acce...

Descripción completa

Detalles Bibliográficos
Autores principales: Thrall, Elizabeth S., Kath, James E., Chang, Seungwoo, Loparo, Joseph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735139/
https://www.ncbi.nlm.nih.gov/pubmed/29255195
http://dx.doi.org/10.1038/s41467-017-02333-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735139/
https://www.ncbi.nlm.nih.gov/pubmed/29255195
http://dx.doi.org/10.1038/s41467-017-02333-2

Ejemplares similares