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Entropy and Polarity Control the Partition and Transportation of Drug-like Molecules in Biological Membrane
Partition and transportation of drug in the plasma membrane of a mammalian cell are the prerequisite for its function on target protein. Therefore, comprehensive understanding of the physicochemical properties and mechanism behind these complex phenomena is crucial in pharmaceutical research. By usi...
Autores principales: | Zhu, Qiang, Lu, Yilin, He, Xibing, Liu, Tao, Chen, Hongwei, Wang, Fang, Zheng, Dong, Dong, Hao, Ma, Jing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735159/ https://www.ncbi.nlm.nih.gov/pubmed/29255188 http://dx.doi.org/10.1038/s41598-017-18012-7 |
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