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The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats

RATIONALE: Development and progression of cardiovascular diseases, including hypertension, are often associated with impaired nitric oxide synthase (NOS) function and nitric oxide (NO) deficiency. Current treatment strategies to restore NO bioavailability with organic nitrates are hampered by undesi...

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Detalles Bibliográficos
Autores principales: Paulo, Luciano L., Cruz, Josiane Campos, Zhuge, Zhengbing, Carvalho-Galvão, Alynne, Brandão, Maria C.R., Diniz, Thiago F., Haworth, Sarah McCann, Athayde-Filho, Petrônio F., Lemos, Virginia S., Lundberg, Jon O., Montenegro, Marcelo F., Braga, Valdir A., Carlström, Mattias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735329/
https://www.ncbi.nlm.nih.gov/pubmed/29268201
http://dx.doi.org/10.1016/j.redox.2017.12.004