Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

BACKGROUND: Extracellular lysophosphatidic acid (LPA) species transmit signals via six different G protein-coupled receptors (LPAR1–6) and are indispensible for brain development and function of the nervous system. However, under neuroinflammatory conditions or brain damage, LPA levels increase, the...

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Detalles Bibliográficos
Autores principales: Plastira, I., Bernhart, E., Goeritzer, M., DeVaney, T., Reicher, H., Hammer, A., Lohberger, B., Wintersperger, A., Zucol, B., Graier, W. F., Kratky, D., Malle, E., Sattler, W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735906/
https://www.ncbi.nlm.nih.gov/pubmed/29258556
http://dx.doi.org/10.1186/s12974-017-1024-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735906/
https://www.ncbi.nlm.nih.gov/pubmed/29258556
http://dx.doi.org/10.1186/s12974-017-1024-1

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